VPN Tablets 20Mg (1 Box = 14 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

 Vonoprazan

Used For

Acidity & Ulcers

How it works

Vonoprazan is a potassium competitive acid blocker (P-CAB) and does not require activation by acid. It inhibits H+, K+-ATPase in a reversible and potassium-competitive manner. Vonoprazan has a strong basicity and resides on the acid production site of gastric parietal cells for a long time, thereby inhibiting gastric acid production. Vonoprazan exerts a strong inhibitory effect on formation of mucosal damage in upper part of the gastrointestinal tract.

Dosage

 Vonoprazan

Side Effects

Diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea, abdominal distension, gamma-glutamyl transferase increased, AST increased, Liver function test abnormal, ALT increased, ALP increased, LDH increased, ? - GPT increased, edema and eosinophilia.

Drug Interactions

CYP3A4 inhibitors Clarithromycin , Digoxin, Methyldigoxin , Itraconazole, Tyrosine kinase inhibitors , Gefitinib, Nilotinib, , Erlotinib

Indication

Vonoprazan is indicated for: Gastric ulcer, duodenal ulcer, reflux esophagitis, prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration, prevention of recurrence of gastric or duodenal ulcer during non-steroidal anti-inflammatory drug (NSAID) administration.

When not to Use

Vonoprazan is contraindicated in: • Patients with hypersensitivity to Vonoprazan or to any excipient of the product. • Patients receiving atazanavir sulphate, nelfinavir or rilpivirine hydrochloride.

Precaution

At the treatment, the course of the disease should closely be observed and the minimum therapeutic necessity should be used according to the disease condition.

Warning 1

In the maintenance of healing of reflux esophagitis, Vonoprazan should be administered only to the patients who repeat recurrence and recrudescence of the condition. Administration to the patients who do not necessitate maintenance of healing should be avoided.

Warning 2

When the healing is maintained over a long period and when there is no risk of recurrence, the dose reduction to a dose of 10mg from a dose 20mg, or suspension of administration should be considered.

Warning 3

Vonoprazan should be administered with care in patients with renal disorders as a delay in the excretion of Vonoprazan may occur, which may result in an increase in the concentration of Vonoprazan in the blood.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.