Trulicity Injection 1.5Mg/0.5Ml (1 Box = 4 Injections)

Requires Prescription (YES/NO)

Yes

Generics

Dulaglutide

Used For

Diabetes Management

How it works

It contains dulaglutide, which is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist. The molecule consists of 2 identical disulfide-linked chains, each containing a modified human GLP-1 analogue sequence covalently linked to a modified human immunoglobulin G4 (IgG4) heavy chain fragment (Fc) by a small peptide linker. The GLP-1 analogue portion of dulaglutide is approximately 90% homologous to native human GLP-1 (7-37). It is used to lower blood sugar (glucose) in adults with type 2 diabetes mellitus and can help prevent heart disease.

Dosage

Dulaglutide

Side Effects

Very common: may affect more than 1 in 10 people - Feeling sick (nausea) – this usually goes away over time - Being sick (vomiting) – this usually goes away over time - Diarrhoea – this usually goes away over time - Stomach (abdominal) pain . Common: may affect up to 1 in 10 people : Low blood sugar (hypoglycaemia) is common when dulaglutide is used alone, or with both metformin and pioglitazone together, or with a sodium-glucose co-transporter 2 inhibitor (SGLT2i) with or without metformin - Feeling less hungry (decreased appetite) - Indigestion - Constipation - Gas (flatulence) - Bloating of the stomach - Reflux or heartburn (also called gastroesophageal reflux disease – GERD) - a disease caused by stomach acid coming up into the tube from your stomach to your mouth - Burping - Feeling tired - Increased heart rate - Slowing of the electrical currents in the heart. Uncommon: may affect up to 1 in 100 people - Injection site reactions (e.g. rash or redness) - Allergic reactions (hypersensitivity) (e.g. swelling, raised itchy skin rash (hives)) - Dehydration, often associated with nausea, vomiting and/or diarrhoea - Gallstones - Inflamed gallbladder

Drug Interactions

Acetaminophen , Atorvastatin , Digoxin , Anti-hypertensives ( lisinopril , metoprolol ) , Warfarin , Oral Contraceptives , Metformin , Sitagliptin .

Indication

It is indicated for the once-weekly treatment of adult patients with type 2 diabetes mellitus to improve glycemic control, in combination with: *Diet and exercise in patients for whom metformin is inappropriate due to contraindication or intolerance. *Metformin, when diet and exercise plus maximal tolerated dose of metformin do not achieve adequate glycemic control. *Metformin and a sulfonylurea, when diet and exercise plus dual therapy with metformin and a sulfonylurea do not achieve adequate glycemic control.

When not to Use

* Patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container. * In patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2 .* During Pregnancy or in breast-feeding women.

Precaution

It causes an increase in heart rate . Increases in heart rate may lead to worsening of cardiac conditions in patients with a history of ischemic heart disease or tachyarrhythmias. Caution should be observed in these patient populations.

Warning 1

It should not be used in patients with type 1 diabetes mellitus or for the treatment of patients with diabetic ketoacidosis.

Warning 2

Patients receiving Dulaglutide in combination with an insulin secretagogue (for example, a sulfonylurea) or insulin may have an increased risk of hypoglycemia. The risk of hypoglycemia may be lowered by a reduction in the dose of the insulin secretagogue or insulin.

Warning 3

Patients treated with dulaglutide should be advised of the potential risk of dehydration and take precautions to avoid fluid depletion.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store in a refrigerator (2°C–8°C). Do not Freeze .