Tio-veez Capsules 18Mcg (1 Strip = 10 Capsules)

Requires Prescription (YES/NO)

Yes

Generics

Tiotropium Bromide

Used For

Chronic Obstructive Pulmonary Disease

How it works

Tiotropium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors, M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3-receptors at the smooth muscle leading to bronchodilation. The effect was dose dependent and lasted longer than 24h. The long duration is probably due to the very slow dissociation from the M3 receptor. The bronchodilation following inhalation of tiotropium is predominantly a site-specific effect.

Dosage

Tiotropium Bromide

Side Effects

Common: Dry mouth.Uncommon: Dizziness, headache, taste disorders, vision blurred, atrial fibrillation, pharyngitis, dysphonia, cough, gastro-oesophageal reflux disease, constipation, oropharyngeal candidiasis, rash, dysuria and urinary retention.Rare: Insomnia, glaucoma, intraocular pressure increased, supraventricular tachycardia, tachycardia, palpitations, bronchospasm, epistaxis, laryngitis, sinusitis, intestinal obstruction, including ileus paralytic, gingivitis, glossitis, dysphagia, stomatitis, nausea, urticaria, pruritus, hypersensitivity (including immediate reactions), angioedema and urinary tract infection.Not Known: Dehydration, dental caries, anaphylactic reaction, skin infection, skin ulcer, dry skin and joint swelling.

Drug Interactions

Sympathomimetics, Methylxanthines, Steroids : Tiotropium has been used concomitantly with short-acting and long-acting sympathomimetic (beta-agonists) bronchodilators, methylxanthines, and oral and inhaled steroids without increase in adverse reactions.Anticholinergics : There is potential for an additive interaction with concomitantly used anticholinergic medications. Therefore, avoid coadministration of tiotropium with other anticholinergic-containing drugs as this may lead to an increase in anticholinergic adverse effects.

Indication

Tiotropium is indicated for the long-term, once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Tiotropium is indicated to reduce exacerbations in COPD patients .

When not to Use

Tiotropium is contraindicated in patients with hypersensitivity to the active substance or to any excipient or to atropine and its derivatives, e.g. ipratropium or oxitropium.

Precaution

Tiotropium is intended as a once-daily maintenance treatment for COPD and should not be used for relief of acute symptoms, i.e., as rescue therapy for the treatment of acute episodes of bronchospasm.

Warning 1

Immediate hypersensitivity reactions, including urticaria, angioedema (including swelling of the lips, tongue, or throat), rash, bronchospasm, anaphylaxis, or itching, may occur after administration of tiotropium. If such a reaction occurs, therapy with tiotropium should be stopped at once and alternative treatments should be considered.

Warning 2

Inhaled medicines, including tiotropium, may cause paradoxical bronchospasm. If this occurs, it should be treated immediately with an inhaled short acting beta2-agonist such as salbutamol. Treatment with tiotropium should be stopped and other treatments considered.

Warning 3

As a predominantly renally excreted drug, patients with moderate to severe renal impairment (creatinine clearance of <60mL/min) treated with tiotropium should be monitored closely for anticholinergic side effects.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.