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Yes
Tadalafil
Male Infertility
Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The mechanism for reducing BPH symptoms has not been established.
Tadalafil
Body as a Whole : Asthenia, face edema, fatigue, pain ; Cardiovascular : Angina pectoris, chest pain, hypotension, myocardial infarction, postural hypotension, palpitations, syncope, tachycardia ; Digestive : Abnormal liver function tests, dry mouth, dysphagia, esophagitis, gastritis, GGTP increased, loose stools, nausea, upper abdominal pain, vomiting, gastroesophageal reflux disease, hemorrhoidal hemorrhage, rectal hemorrhage ; Musculoskeletal : Arthralgia, neck pain ; Nervous : Dizziness, hypesthesia, insomnia, paresthesia, somnolence, vertigo ; Renal and Urinary : Renal impairment ; Respiratory : Dyspnea, epistaxis, pharyngitis ; Skin and Appendages : Pruritus, rash, sweating ; Ophthalmologic : Blurred vision, changes in color vision, conjunctivitis (including conjunctival hyperemia), eye pain, lacrimation increase, swelling of eyelids ; Otologic : Sudden decrease or loss of hearing, tinnitus ; Urogenital : Erection increased, spontaneous penile erection .
An alpha blocker (used to treat high blood pressure or urinary symptoms associated with benign prostatic hyperplasia) , other medicines to treat high blood pressure , riociguat , a 5- alpha reductase inhibitor (used to treat benign prostatic hyperplasia) , medicines such as ketoconazole tablets (to treat fungal infections) and protease inhibitors for treatment of AIDS or HIV infection , phenobarbital, phenytoin and carbamazepine (anticonvulsant medicines) , rifampicin, erythromycin , clarithromycin or itraconazole , other treatments for erectile dysfunction.
Treatment of erectile dysfunction in adult males .It i is also indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).
It is contraindicated in patients with a known serious hypersensitivity to tadalafil .
Physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Therefore, treatments for erectile dysfunction, including Tadalafil, should not be used in men for whom sexual activity is inadvisable as a result of their underlying cardiovascular status. Patients who experience symptoms upon initiation of sexual activity should be advised to refrain from further sexual activity and seek immediate medical attention.
There have been rare reports of prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) for this class of compounds. Priapism, if not treated promptly, can result in irreversible damage to the erectile tissue. Patients who have an erection lasting greater than 4 hours, whether painful or not, should seek emergency medical attention.
Physicians should advise patients to stop taking PDE5 inhibitors, including Tadalafil, and seek prompt medical attention in the event of sudden decrease or loss of hearing. These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including Tadalafil. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors .
Caution is advised when PDE5 inhibitors are coadministered with alpha blockers. PDE5 inhibitors, including Tadalafil, and alpha-adrenergic blocking agents are both vasodilators with blood-pressure-lowering effects. When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. In some patients, concomitant use of these two drug classes can lower blood pressure significant, which may lead to symptomatic hypotension (e.g., fainting).
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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