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Yes
Nortriptylline
Depression
Nortriptyline is a tricyclic antidepressant with actions and uses similar to these of Amitriplyline. It is the principal active metabolite of Amitriplyline.
Nortriptylline
Anti-cholinergic effects (e.g. dry mouth , blurred vision ) , drowsiness , fatigue , neurological effects , GI upset , weight gain , hot flushes , psychiatric effects , hypotension , tachycardia , arrthymias , heart block , MI , allergic skin reactions , heart block , MI , allergic skin reactions , taste disturbances , tinnitus. Rarely, SIADH , hepatitis , blood dyscrasias , bone marrow depression.
Monoamine oxidase inhibitors , adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine , guanethidine, debrisoquine, bethanidine and possibly clonidine , Barbiturates.
Nortriptyline is indicated for the relief of symptoms of depression. It may also be used for the treatment of some cases of nocturnal enuresis.
Hypersensitivity to the active substance or to any of the excipients .
Depression is associated with an increased risk of suicidal thoughts, self-harm and suicide (suicide-related events). This risk persists until significant remission occurs. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs. It is general clinical experience that the risk of suicide may increase in the early stages of recovery.
Patients with cardiovascular disease should be given nortriptyline only under close supervision because of the tendency of the drug to produce sinus tachycardia and to prolong the conduction time. Myocardial infarction, arrhythmia and strokes have occurred. Great care is necessary if nortriptyline is administered to hyperthyroid patients or to those receiving thyroid medication, since cardiac arrhythmias may develop.
The use of nortriptyline in schizophrenic patients may result in an exacerbation of the psychosis or may activate latent schizophrenic symptoms. If administered to overactive or agitated patients, increased anxiety and agitation may occur. In manic-depressive patients, nortriptyline may cause symptoms of the manic phase to emerge.
If possible, the use of nortriptyline should be avoided in patients with narrow angle glaucoma or symptoms suggestive of prostatic hypertrophy.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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