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Paracetamol , Chlorpheniramine maleate , Pseudoephedrine Hydrochloride
Fever & Cough
Paracetamol works to stop the pain messages from getting through to the brain. It also acts in the brain to reduce fever . Chlorpheniramine maleate : This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose. Pseudoephedrine is a sympathomimetic with a mixed mechanism of action, direct and indirect. It indirectly stimulates alpha-adrenergic receptors, causing the release of endogenous norepinephrine from the granularity of neurons, while it directly stimulates beta-adrenergic receptors.
Paracetamol , Chlorpheniramine maleate , Pseudoephedrine Hydrochloride
Paracetamol : Thrombocytopaenia, Anaphylaxis cutaneous hypersensitivity reactions including amoung others skin rashes, angiodema, stevens johnson syndrome, toxic epidermal necrosis, bronchospasm in patients sensitive to aspirin and other NSAIDs, hepatic dysfuction.Psuedoephedrine: Nervousness, Headache, Dizziness, Insomnia, Increased blood pressure, Vomiting, nausea, Mydriasis, acute angle closure glaucoma, most likely to occur in those with closed angle glaucoma Tachycardia, Palpitations Allergic reactions (e.g. rash, urticaria, allergic dermatitis) Dysuria, urinary retention. This is most likely to occur in those with bladder outlet obstruction such as prostatic hypertrophy.Chlorphenamine : Allergic reactions, angioedema, anaphylactic reactions Anorexia, Confusion*, excitation*, irritability*, nightmares*, Disturbance in attention, abnormal coordination, dizziness, headache Sedation, somnolence Blurred vision, Hypotension, Thickening of bronchial, Secretions, Nausea, dry mouth, Vomiting, abdominal pain, diarrhoea, dyspepsia, Exfoliative dermatitis, rash, urticaria, photosensitivity, Muscle twitching, muscle Weakness, Urinary retention, Fatigue, Chest tightness.
The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol-containing products with increased risk of bleeding; occasional doses have no significant effect. Concomitant administration of pseudoephedrine hydrochloride-containing products andMAOIs (or within two weeks of stopping of MAOI) may lead to hypertensive crisis. Theanticholinergic effects of chlorphenamine are intensified by MAOIs. Concomitant use of this medication with sympathomimetic agents (such asdecongestants, appetite suppressants and amphetamine-like psychostimulants) which interfere with the catabolism of sympathomimetic amines, may occasionally cause a rise in blood pressure (see Contraindications). Pseudoephedrine-containing products may antagonise the effect of certain classes ofantihypertensives (e.g. beta blockers, methyl-dopa, reserpine, debrisoquine, guanethidine).Concurrent use of chlorphenamine and hypnotics or anxiolytics may potentiatedrowsiness. Concurrent use of alcohol may have a similar effect.Chlorphenamine inhibits phenytoin metabolism and can lead to phenytoin toxicity.
It is used in : Common cold , Influenza , Fever associated with common cold and flu , Muscle ache, Nasal congestion , Sinus congestion , Headache and sinus pain , Sneezing , Itchy and watery eyes .
This product is contraindicated in patients: -With a previous history of hypersensitivity to paracetamol, pseudoephedrine, chlorphenamine, other antihistamines or excipients.- With severe hypertension or severe coronary artery disease.-Who are receiving other sympathomimetics (such as decongestants, appetite suppressants and amphetamine-like psychostimulants).-Who are receiving Monoamine Oxidase Inhibitors (MAOIs), or for two weeks after stopping a MAOI drug.-With severe renal impairment.
Contains paracetamol. Do not use with any other paracetamol-containing products, decongestants, antihistamines or cold and flu medicines. The concomitant use with other products containing paracetamol may lead to an overdose. Paracetamol overdose may cause liver failure which can lead to liver transplant or death.
Caution should be exercised in patients with mild to moderate kidney impairment and in those with hepatic impairment. Underlying liver disease increases the risk of paracetamol-related liver damage.
Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index or are chronic heavy users of alcohol.
Caution should be exercised in patients with cardiovascular disease, arrhythmias, hypertension, hyperthyroidism, prostatic enlargement, diabetes, glaucoma, phaeochromocytoma, epilepsy, bronchitis, bronchiectasis and bronchial asthma.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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