Pletaal Tablets 50Mg (1 Strip = 10 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

Cilostazol

Used For

Blood Clot

How it works

Cilostazol and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.

Dosage

Cilostazol

Side Effects

Headache , diarrhoea , abnormal stools , ecchymosis , oedema , dizziness , palpitation , tachycardia, angina , arrhythmia , ventricular extrasystole , rhinitis , GI upset , anorexia , pharyngitis , rash , pruritius , chest pain , asthaenia . Reports of blood dyscrasias.

Drug Interactions

Cimetidine , diltiazem , erythromycin , clarithromycin , ketoconazole , lansoprazole , omeprazole , protease inhibitors , cisapride , midazolam , nifedipine , verapamil , other inhibitors or substrates of CYP3A4 or 2C19 . Highly protein bound drugs , hypotensive agents , aspirin , antiplatelets , clopidogrel , anticoagulants , vasodilators , statins , pimozide , ergot derivatives , inducers of CYP3A4 or 2C19 ( e.g., anticonvulsants , rifampicin , St.John's wort ).

Indication

1. Treatment of ischemic symptoms including ulceration , pain and coldness of the extremities, in chronic arterial occlusion (Buerger's disease. arteriosclerosis obliterans, diabetic peripheral angiopathy).2. Prevention of recurrence of cerebral infarction (excluding cardiogenic cerebral embolism).

When not to Use

Severe renal impairment , moderate to severe hepatic impairement , congestive herat failure , predisposition to bleeding , history of ventricular tachycardia , multifocal ventricular ectopics or severe tachycardia . QTc prolongation , unstable angina , recent MI or coronary intervention

Precaution

Cilostazol should not be administered to patients with cerebral infarction until their condition has stabilized.

Warning 1

Attention should be paid to cerebral infarction patients wno are receiving other anti-platelet agents, or to hypertension patients, whose blood pressure should be well- controlled during treatment.

Warning 2

Attention should be paid to cerebral infarction patients wno are receiving other anti-platelet agents, or to hypertension patients, whose blood pressure should be well- controlled during treatment.

Warning 3

Cilostazol may cause dizziness and patients should be warned to exercise caution before they drive or operate machinery.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.