Pexot Cr Tablets 25Mg (1 Strip = 10 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

Paroxetine HCl

Used For

Depression

How it works

The efficacy of paroxetine in the treatment of major depressive disorder, social anxiety disorder, obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD) is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin (5-hydroxy-tryptamine, 5-HT).

Dosage

Paroxetine HCl

Side Effects

Abnormal bleeding, predominantly of the skin and mucous membranes (mostly ecchymosis), thrombocytopenia , allergic reactions (including urticaria and angioedema , syndrome of inappropriate anti-diuretic hormone secretion (SIADH) , hyponatraemia , somnolence, insomnia, agitation, abnormal dreams (including nightmares) , confusion, hallucinations , dizziness, tremor, headache.

Drug Interactions

L-tryptophan, triptans, tramadol, SSRIs, lithium, fentanyl and St. John’s Wort – Hypericum perforatum – preparations , Pimozide , carbamazepine, rifampicin, phenobarbital, phenytoin , Fosamprenavir , ritonavir , Procyclidine , carbamazepine, phenytoin, sodium valproate , tricyclic antidepressants, phenothiazine neuroleptics, risperidone, atomoxetine, certain Type 1c antiarrhythmics and metoprolol.

Indication

It is indicated for the symptomatic relief of Major Depressive Disorder.

When not to Use

Known hypersensitivity to paroxetine and excepients. Paroxetine should not be used in combination with monoamine oxidase (MAO) inhibitors (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor) or within 2 weeks of terminating treatment with MAO inhibitors. Likewise, MAO inhibitors should not be introduced within 2 weeks of cessation of therapy with paroxetine.

Precaution

Treatment with antidepressants is associated with an increased risk of suicidal thinking and behaviour in children and adolescents with Major Depressive Disorder (MDD) and other psychiatric disorders.

Warning 1

Epidemiological studies on bone fracture risk following exposure to some antidepressants, including SSRIs, have reported an association with fractures. The risk occurs during treatment and is greatest in the early stages of therapy. The possibility of fracture should be considered in the care of patients treated with paroxetine.

Warning 2

Caution is recommended in patients with severe renal impairment or in those with hepatic impairment.

Warning 3

Overall the incidence of seizures is less than 0.1% in patients treated with paroxetine. The drug should be discontinued in any patient who develops seizures.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.