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Yes
Domperidone Maleate , Cinnarizine
Nausea & Vomiting
It works by blocking the action of dopamine (a chemical messenger) in the brain which causes nausea and vomiting.
Domperidone Maleate , Cinnarizine
It can cause Dry mouth, Headache, Dizziness, Nervousness, Flushing, Irritability, Stomach Cramps, Leg cramps, Chest pain, Difficulty urinating .
CYP3A4 inhibitors such as indinavir , Anti arrhythmics class IA (e.g., disopyramide, quinidine), anti arrhythmics class III (e.g., amiodarone, dofetilide, dronedarone, ibutilide, sotalol), certain antipsychotics (e.g., haloperidol, pimozide, sertindole), certain antidepressants (e.g., citalopram, escitalopram), certain antibiotics (e.g., levofloxacin, moxifloxacin), certain antifungal agents (e.g., pentamidine), certain antimalarial agents (e.g., halofantrine), certain gastro intestinal drugs (e.g., dolasetron), certain drugs used in cancer (e.g., toremifene, vandetanib), certain other drugs (e.g., bepridil, methadone).
It is used to relieve the symptoms of stomach disorders, nausea, and vomiting.
It is contraindicated in the following situations: • In patients with moderate to severe hepatic impairment • In patients who have known existing prolongation of cardiac conduction intervals (particularly QTc) and in patients with significant electrolyte disturbances or underlying cardiac diseases such as congestive heart failure.
Epidemiological studies have shown domperidone may be associated with an increased risk of serious ventricular arrhythmias or sudden cardiac death.
Patients older than 60 years of age should consult their physician before taking domeperidone maleate.
Due to increased risk of ventricular arrhythmia, domeperidone maleate is not recommended in patients with known existing prolongation of cardiac conduction intervals, particularly QTc, in patients with significant electrolyte disturbances.
Treatment with domeperidone maleate should be stopped if signs or symptoms occur that may be associated with cardiac arrhythmia, and the patient should promptly consult their physician.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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