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Yes
Carbimazole
Hyperthyroidism
Carbimazole, a thionamide, is a pro-drug which undergoes rapid and virtually complete metabolism to the active metabolite, thiamazole, also known as methimazole. The method of action is believed to be inhibition of the organification of iodide and the coupling of iodothyronine residues which in turn suppress the synthesis of thyroid hormones.
Carbimazole
Sore throat , mouth ulcers , high temperature or fever , itching , increased bruising or bleeding tendency , you are feeling generally unwell or think that you may have an infection , angioedema, a serious allergic reaction with symptoms that may include swollen tongue, lips, face or throat .
• Iodine or any preparation containing iodine • Theophylline, used to treat asthma or breathing problems • Medicines called anticoagulants, which are used to thin blood e.g. warfarin • Prednisolone, used to treat allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis or breathing disorders • Erythromycin, used to treat bacterial infections • Digitalis, used to treat heart conditions • Beta-blockers, used to treat heart conditions and high blood pressure.
It is used to treat hyperthyroidism or overactive thyroid gland a condition where the thyroid gland produces too much thyroid hormone).
Do not take this medicine if you have an allergy to: • Any medicine containing carbimazole • Any of the ingredients listed .
Precaution should be taken in patients with intrathoracic goitre, which may worsen during initial treatment with carbimazole. Tracheal obstruction may occur due to intrathoracic goitre.
Bone marrow depression including neutropenia, eosinophilia, leucopenia and agranulocytosis has been reported. Fatalities with carbimazole-induced agranulocytosis have been reported.
Patients should always be warned about the onset of sore throats, bruising or bleeding, mouth ulcers, fever and malaise and should be instructed to stop the drug and to seek medical advice immediately. In such patients, white blood cell counts should be performed immediately, particularly where there is any clinical evidence of infection.
Carbimazole should be used with caution in patients with mild-moderate hepatic insufficiency. If abnormal liver function is discovered, the treatment should be stopped. The half-life may be prolonged due to the liver disorder.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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