Musidin Capsules 4Mg (1 Box = 10 Capsules)

Requires Prescription (YES/NO)

Yes

Generics

Tizanidine

Used For

Muscle Spasm

How it works

Tizanidine is a centrally acting skeletal muscle relaxant. Its principal site of action is the spinal cord, where the evidence suggests that, by stimulating presynaptic alpha2-receptors, it inhibits the release of excitatory aminoacids that simulate N-methyl-D-aspartate (NMDA) receptors. Polysynaptic signal transmission at spinal interneuron level, which is responsible for excessive muscle tone, is thus inhibited and muscle tone reduced.

Dosage

Tizanidine

Side Effects

Psychiatric disorders: Rare: Hallucination, insomnia, sleep disorder . Nervous system disorders: Common: Bradycardia . Vascular disorders - Common: Hypotension . Gastrointestinal disorders Common: Dry mouthRare:Nausea, gastrointestinal disorder Hepatobiliary disorders: Very rare: Hepatitis Musculoskeletal and connective tissue disorders Rare: Muscular weakness General disorders and administration site conditions Common: Fatigue.

Drug Interactions

Fluvoxamine or ciprofloxacin, CYP4501A2 inhibitors , antiarrhythmics (amiodarone, mexiletine, propafenone) cimetidine, some fluoroquinolones ( enoxacin, pefloxacin, norfloxacin) rofecoxaib, oral contraceptives and ticlopidine , Alcohol and sedatives.

Indication

Painful muscle spasms: Associated with static and functional disorders of the spine (cervical and lumber syndromes). Following surgery, e.g. for herniated intervertebral disc or osteoarthritis of the hip. Spasticity due to neurological disorders: Eg. multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebrovascular accidents, and cerebral palsy.

When not to Use

Known hypersensitivity to tizanidine or any component of the formulation. Significantly impaired hepatic function. Concomitant use of tizanidine with fluvoxamine or ciprofloxacin is contraindicated.

Precaution

Hallucinations (visual) may occur while you are using this medicine. Check with your doctor right away if you have hallucinations (seeing things that are not there).

Warning 1

These contain lactose. The medicine is not recommended in patients with rare hereditary problem of galactose intolerance, of severe lactase deficiency or of glucose galactose malabsorption.

Warning 2

Patients experiencing somnolence or dizziness should refrain from activity requiring a high degree of alertness. e.g: driving a vehicle or operating machine.

Warning 3

Concomitant use of tizanidine with CYP1A2 inhibitors is not recommended since hepatic dysfunction has been reported.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.