Motilium-V Tablets 12.72Mg (1 Strip = 20 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

Domeperidone Maleate

Used For

Nausea & Vomiting

How it works

Its anti emetic effect may be due to a combination of peripheral (gastrokinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood brain barrier in the area postrema.

Dosage

Domeperidone Maleate

Side Effects

Depression (2.5%) Anxiety (1.6%) Libido Decreased/Loss of Libido , Headache (5.6%) , Somnolence (2.5%) , Akathisia (1%) , Diarrhea (5.2%) , Rash (2.8%), Pruritus (1.7%) , Breast Enlargement / Gynaecomastia (5.3%) Breast Tenderness (4.4%), Galactorrhoea (3.3%) , Amenorrhea (2.9%) , Breast Pain (2.3%), , Menstruation Irregular (2.0%) , Lactation Disorder (1.6%).

Drug Interactions

CYP3A4 inhibitors such as indinavir , Anti arrhythmics class IA (e.g., disopyramide, quinidine), anti arrhythmics class III (e.g., amiodarone, dofetilide, dronedarone, ibutilide, sotalol), certain antipsychotics (e.g., haloperidol, pimozide, sertindole), certain antidepressants (e.g., citalopram, escitalopram), certain antibiotics (e.g., levofloxacin, moxifloxacin), certain antifungal agents (e.g., pentamidine), certain antimalarial agents (e.g., halofantrine), certain gastro intestinal drugs (e.g., dolasetron), certain drugs used in cancer (e.g., toremifene, vandetanib), certain other drugs (e.g., bepridil, methadone).

Indication

It is used in the treatment of nausea and vomiting.

When not to Use

Domeperidone is contraindicated in the following situations: • In patients with moderate to severe hepatic impairment • In patients who have known existing prolongation of cardiac conduction intervals (particularly QTc) and in patients with significant electrolyte disturbances or underlying cardiac diseases such as congestive heart failure.

Precaution

Epidemiological studies have shown domperidone may be associated with an increased risk of serious ventricular arrhythmias or sudden cardiac death.

Warning 1

Patients older than 60 years of age should consult their physician before taking domeperidone maleate.

Warning 2

Due to increased risk of ventricular arrhythmia, domeperidone maleate is not recommended in patients with known existing prolongation of cardiac conduction intervals, particularly QTc, in patients with significant electrolyte disturbances.

Warning 3

Treatment with domeperidone maleate should be stopped if signs or symptoms occur that may be associated with cardiac arrhythmia, and the patient should promptly consult their physician.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.