Mirboli 5mg Tablets (1 Strip = 10 Tablets)

1 box = 3 Strips

Mirboli 5mg Tablets

Requires Prescription (YES/NO)

Yes

Generics

Mirogabalin

Used For

Neuropathic Pain

How it works

Mirogabalin is considered to exhibit its analgesic effect by reducing calcium current via binding to the a2 subunit, which plays an auxiliary role in functions of voltage-gated calcium channels in the nervous system. The analgesic effect of mirogabalin is also suggested to involve activation of the noradrenergic pathway in the descending pain inhibitory system.

Dosage

Dosage : Adults: Initially, 5 mg twice daily. Increase the dose by 5 mg/dosing with an interval of at least 1 wk up to 15 mg twice daily. Dose may be increased or decreased between 10 mg and 15 mg twice daily, based on patient’s age or symptoms. Max : 15 mg twice daily. Children : Not recommended.

Side Effects

Somnolence , dizziness , perpheral oedema , weight gain .

Drug Interactions

Mirogabalin is predominantly excreted by renal glomerular filtration and tubular secretion. The Transporters involved in the secretion of mirogabalin are organic anion transporter (OAT) 1, OAT3, organic cation transporter (OCT) 2, H+/organic cation antiporter (MATE) 1, and MATE2-K. Mirogabalin is also metabolized by UDP-glucuronosyltransferases (UGTs)

Indication

Mirogabalin is indicated for the treatment of neuropathic pain in adult .

When not to Use

Patients with a history of hypersensitivity to the active substance or to any of the excipients.

Precaution

Dizziness, somnolence, and loss of consciousness, which may cause falls and subsequent fractures, etc., may occur. Patients being treated with MIROGABALIN should be monitored closely; if any abnormalities are noted, appropriate measures, such as discontinuation of treatment or dose reduction, should be taken .

Warning 1

Treatment with MIROGABALIN may cause weight gain. Caution should therefore be exercised for potential occurrence of obesity. If signs of obesity are noted, appropriate measures, such as diet and/or exercise therapy, should be taken. In particular, since weight gain may be associated with dose increase or long-term use, body weight should be measured regularly .

Warning 2

Abrupt discontinuation of treatment with MIROGABALIN may cause drug withdrawal symptoms (e.g., insomnia, nausea, diarrhea, decreased appetite). Treatment with MIROGABALIN should be discontinued in a careful manner, such as gradual dose reduction.

Warning 3

Treatment with MIROGABALIN may cause ophthalmic disorders (e.g., amblyopia, abnormal vision, vision blurred, and diplopia). Caution should therefore be exercised for potential occurrence of ophthalmic disorders in medical examinations including careful history taking

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.