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Specification
Requires Prescription (YES/NO)
Yes
Generics
Mirtazapine
Used For
Depression
How it works
Mirtazapine is a centrally active presynaptic a2 -antagonist, which increases central noradrenergic and serotonergic neurotransmission. The enhancement of serotonergic neurotransmission is specifically mediated via 5-HT1 receptors, because 5-HT2 and 5-HT3 receptors are blocked by Mirtazapine. The histamine H1-antagonistic activity of Mirtazapine is associated with its sedative properties.
Usage And Safety
Dosage
Mirtazapine
Side Effects
Bone marrow depression (granulocytope-nia, agranulo-cytosis, aplastic anaemia, thrombo-cytopenia) , Eosinophilia , Weight increased , Increase in appetite Abnormal dreams , Confusion , Anxiety , Insomnia , Nightmares , Mania , Agitation , Hallucinations , Psychomotor restlessness (incl. akathisia, hyperkinesia) , Aggression , Suicidal ideation , Suicidal behaviour , Somnolence Sedation , Headache , Lethargy , Dizziness , Tremor , Paraesthesia , Restless legs, Syncope, Myoclonus , Convulsions (insults) , Serotonin syndrome , Oral paresthaesia , Dysarthria.
Drug Interactions
MAO inhibitors , SSRIs , benzodiazepines and other sedatives (notably most antipsychotics, histamine H1 antagonists, opioids , alcohol.
Indication
Treatment of episodes of major depression in adults.
When not to Use
• Hypersensitivity to the active substance • Concomitant use of Mirtazapine with monoamine oxidase (MAO) inhibitors.
Precautions
Precaution
Mirtazapine should not be used in the treatment of children and adolescents under the age of 18 years. Suicide-related behaviors (suicide attempt and suicidal thoughts), and hostility (predominantly aggression, oppositional behavior and anger) may occur among children and adolescents treated with antidepressants.
Warnings
Warning 1
The patient should be carefully monitored for the appearance of suicidal symptoms.
Warning 2
Bone marrow depression, usually presenting as granulocytopenia or agranulocytosis, may occur rarely during treatment with Mirtazapine.
Warning 3
Treatment should be discontinued if jaundice occurs.
Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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