Lasoride Tablets 40Mg/5Mg (1 Strip = 10 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

Furosemide + Amiloride

Used For

Heart Failure

How it works

Furosemide : Furosemide is a loop diuretic which acts primarily to inhibit electrolyte reabsorption in the thick ascending Loop of Henle. Excretion of sodium, potassium and chloride ions is increased and water excretion enhanced . Amiloride : Amilorideis a mild diuretic which moderately increases the excretion of sodium and chloride and reduces potassium excretion, and appears to act mainly on the distal renal tubules. It does not appear to act by inhibition of aldosterone and does not inhibit carbonic anhydrase. Amiloride adds to the natiuretic but diminishes the kaliuretic effect of other diuretics.A combination of Furosemide and Amiloride is a diuretic which reduces the potassium loss of furosemide alone while avoiding the possible gastro-intestinal disturbances of potassium supplements .

Dosage

Furosemide + Amiloride

Side Effects

Bruising more easily, getting more infections, feeling weak or tired more than usual , Increased thirst, headache, feeling dizzy or light-headed, fainting, confusion, muscle or joint pains or weakness, cramps or spasms, stomach upsets or uneven heartbeats , Blistering or peeling of the skin around the lips, eyes, mouth, nose and genitals, flu-like symptoms and fever .

Drug Interactions

Ramipril, enalapril, perindopril (called ‘ACE inhibitors’) or losartan, candesartan, irbesartan (called ‘angiotensin II receptor antagonists’) , Medicines used as a general anaesthetic , Medicines for diabetes , Theophylline , Phenytoin , Lithium , Cisplatin , Digoxin , aspirin, ibuprofen, ketoprofen or indometacin , Carbamazepine , Aminoglutethimide , Ciclosporin , Methotrexate , Carbenoxolone , Reboxetine , Amphotericin , Corticosteroids , salbutamol, terbutaline sulphate, salmeterol, formoterol or bambuterol , HIV medicine , gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin or high doses of cephalosporins

Indication

It is a potassium sparing diuretic which is indicated where a prompt diuresis is required. It is of particular value in conditions where potassium conservation is important: congestive cardiac failure, nephrosis, corticosteroid therapy, oestrogen therapy and for ascites associated with cirrhosis.

When not to Use

You are allergic (hypersensitive) to furosemide, amiloride hydrochloride or any of the other ingredients of this medicine ; Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue ; You are allergic to sulphonamides such as sulfadiazine or co-trimoxazole ; You have severe problems with your kidneys ; You have severe liver problems .

Precaution

Urinary output must be secured. Patients with partial obstruction of urinary outflow, for example patients with prostatic hypertrophy or impairment of micturition have an increased risk of developing acute retention and require careful monitoring.

Warning 1

It should be used with particular caution in elderly patients or those with potential obstruction of the urinary tract or disorders rendering electrolyte balance precarious.

Warning 2

Caution should be observed in patients liable to electrolyte deficiency. Regular monitoring of serum sodium, potassium, creatinine and glucose is generally recommended during therapy; particularly close monitoring is required in patients at high risk of developing electrolyte imbalances or in case of significant additional fluid loss. Hypovolaemia or dehydration as well as any significant electrolyte and acid-base disturbances must be corrected. This may require temporary discontinuation .

Warning 3

In patients who are at high risk for radiocontrast nephropathy, furosemide is not recommended to be used for diuresis as part of the preventative measures against radiocontrast-induced nephropathy.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.