Genticyn Im/Iv Injection 80Mg (1 Box = 2 Ampoules)

Requires Prescription (YES/NO)

Yes

Generics

Gentamicin

Used For

Bacterial Infection

How it works

Gentamicin, an aminoglycoside antibiotic, is bactericidal. Gentamicin passes through the gram-negative membrane in an oxygen-dependent active transport. As oxygen is required, this is why aminoglycosides are not effective in anaerobic bacteria.

Dosage

Gentamicin

Side Effects

Vestibular and auditory damage , nephrotoxicity , hypomagnesaemia , blood dyscrasias , purpura , nausea , vomiting , stomatitis , signs of liver dysfunction , antibiotic associated colitis , atrophy at injection site , ototoxicity , neuromuscular blockade.

Drug Interactions

Neuromuscular blocking drugs , anaesthetic , ethacrynic acid , furosemide , other nephrotoxic or ototoxic drugs , indometacin , neostigmine , pyrodostigmine , bisphosphonates , oral anticoagulants.

Indication

Serious gentamicin sensitive infections . UTI.

When not to Use

Do not use if you are allergic to any of the ingredients in the list.

Precaution

To avoid adverse events, continuous monitoring (before, during and after) of renal function (serum creatinin, creatinin clearance), control of function of vestibule and cochlea as well as hepatic and laboratory parameters is recommended.

Warning 1

Ototoxicity has been recorded following the use of gentamicin. Groups at special risk include patients with impaired renal function, infants and possibly the elderly. Consequently, renal, auditory and vestibular functions should be monitored in these patients and serum levels determined so as to avoid peak concentrations above 10mg/l and troughs above 2mg/l when administering Gentamicin twice daily and 1mg/l for a once daily dose.

Warning 2

As there is some evidence that risk of both ototoxicity and nephrotoxicity is related to the level of total exposure, duration of therapy should be the shortest possible compatible with clinical recovery. In some patients with impaired renal function there has been a transient rise in blood-urea-nitrogen which has usually reverted to normal during or following cessation of therapy. It is important to adjust the frequency of dosage according to the degree of renal function.

Warning 3

Gentamicin should only be used in pregnancy if considered essential by the physician .

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.