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Specification
Requires Prescription (YES/NO)
Yes
Generics
Estradiol Valerate , Norgestrel
Used For
Hormone Replacement Therapy
How it works
It serves as a replacement of estrogen during menopause and in the period preceding it and thereby improves the symptoms which may appear. The additional hormone in this is progestogen, which contributes to regulation of the bleeding and lowers the chance of developing uterine cancer, in comparison to women treated with estrogen alone.
Usage And Safety
Dosage
Estradiol Valerate , Norgestrel
Side Effects
Occurring often:Weight gain or loss, headache, abdominal pain, nausea, rash, itching, vaginal bleeding including spotting (irregularities in bleeding pattern, usually subside during continued treatment). Occurring infrequently: Allergies (hypersensitivity reaction), depression, dizziness, visual disturbances, palpitations, indigestion, erythema nodosum (a skin condition characterized by reddish painful skin nodules), urticaria (hives), breast pains, breast tenderness, edema. Occurring rarely: Anxiety, decreased or increased libido, migraine, contact lens intolerance, bloating, vomiting, excessive hair growth, acne, muscle cramps, painful periods, vaginal discharge, pre-menstrual-like syndrome, swollen breasts, fatigue.
Drug Interactions
• Medicines to treat epilepsy (such as: phenytoin, phenobarbital); • Antibiotics (such as: rifampicin, rifabutin); • Medicines of the protease inhibitor type to treat the AIDS virus (HIV); • Medicines of the transcriptase inhibitor type to treat the AIDS virus (HIV) (such as: nevirapine, efavirenz); • Herbal preparations containing the herb St. John’s Wort (Hypericum) • Medicines to treat diabetes (such as: insulin).
Indication
A hormonal medicine in two phases to treat irregularities of the menstrual cycle and menopause-related disturbances.
When not to Use
Do not use the preparation if: • You are sensitive (allergic)to the active ingredients or to any of the other components contained in the medicine . • You are suffering from breast cancer or uterine cancer. • You are suffering from vaginal bleeding of an unknown cause. • You are suffering from endometrial hyperplasia that is not being treated. • You are suffering from a blood clot in the leg veins (deep vein thrombosis) or the lung veins (pulmonary embolus) or from other problems related to formation of blood clots.
Precautions
Precaution
Stop taking the medicine and refer to the doctor immediately if you suffer from painful swelling in the leg, sudden chest pain, difficulty breathing. These may be signs of a blood clot. Treatment will only be resumed as soon as the doctor instructs you to do so.
Warnings
Warning 1
Hormone Replacement Therapy is not recommended for women who are suffering or have recently suffered from a heart disease. If you have ever suffered from heart disease, consult with the doctor as to whether it is recommended that you take HRT.
Warning 2
Risk factors for cancer, such as if any of your close relatives had cancer.
Warning 3
Ovarian cancer is serious and very rare. This cancer can be difficult to diagnose because there are sometimes no obvious signs of the disease. Some studies have indicated that taking estrogen-only HRT for more than 5 years may increase the risk of ovarian cancer. It is not yet known whether other kinds of HRT increase the risk to the same degree .
Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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