Dormicum Tablets 7.5Mg (1 Box = 10 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

Midazolam

Used For

Anesthesia

How it works

The central actions of benzodiazepines are mediated through an enhancement of the GABAergic neurotransmission at inhibitory synapeses. In the presence of benzodiazepines, the affinity of the GABA receptor for the neurotransmitter is enhanced through positive allosteric modulation resulting in an increased action of released GABA on the postsynaptic transmembrance chloride ion flux.

Dosage

Midazolam

Side Effects

Fluctuations in vital signs including decreased respiratory effects, variation in blood pressure and pulse rate are the most frequently seen findings. Laryngospasm, bronchospasm, dyspnoea, hyperventilation and airway obstruction.Premature ventricular contraction, vasovagal episode and tachycardia.Retrograde amnesia, euphoria, confusion, nervousness, restlessness, nightmares dysphonia and paresthesia.Blurred vision, diplopia, nystagamus, visual disturbances, blocked ears, loss of balance and light headedness.Headache, hiccough, nausea, vomiting, yawning, lethargy, weakness and faint feeling.

Drug Interactions

Antipsychotics , hypnotics , antidepressants , narcotic analgesics , anticonvulsants , anesthetics , antihistamines , alcohol, erythromycin , cimetidine , diltiazem , verapamil , ketoconazole , fluconazole , itraconazole , cyclosporin , nifedipine , nabilone , muscle relaxants , ulcer healing drugs , xanthines , macrolides , protease inhibitors.

Indication

Short-term treatment of insomnia Benzodiazepines are only indicated when the disorder is severe, disabling or subjecting the individual to extreme distress. - Sedation in premedication before surgical or diagnostic procedures.

When not to Use

It must not be used in patients with:- Severe respiratory insufficiency;- Severe hepatic impairment (benzodiazepines are not indicated to treat patients with severe hepatic impairments as they may cause encephalopathy);- Sleep apnea syndrome;

Precaution

The duration of treatment with benzodiazepine hypnotics should be as short as possible , and should not exceed 2 weeks. The tapering-off process should be tailored to the individual. Extension beyond this period should not take place without re-evaluation of the situation.

Warning 1

Some loss of efficacy to the hypnotic effects of short-acting benzodiazepines may develop after repeated use for a few weeks.

Warning 2

When discontinuing midazolam therapy, insomnia may recur, possibly with a higher severity than before starting treatment (“rebound insomnia”).Therefore, it is recommended that the dosage of midazolam is decreased gradually .

Warning 3

It may cause anterograde amnesia, which occurs most frequently within the first few hours after ingesting the product. In order to reduce the risk, patients should ensure that they are able to have an uninterrupted sleep of 7 – 8 hours .

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.