Deprel Tablets 100Mg (1 Strip = 10 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

Trazodone HCl

Used For

Depression

How it works

Trazodone HCl inhibits serotonin uptake into rat brain synaptosomes and by rat platelets at relatively high concentrations and inhibits brain uptake of noradrenaline in vitro only at very high concentrations. It possesses antiserotonin-adrenergic blocking and analgesic effects. The anticholinergic activity of trazodone is less than that of the tricyclic antidepressants in animal studies and this has been confirmed in therapeutic trials in depressed patients.

Dosage

Trazodone HCl

Side Effects

•Thoughts of harming or killing yourself • Feeling tired, faint, dizzy, having pale skin. These could be signs of anaemia • Convulsions, fits (seizures) • Unusual skin sensations such as numbness, tingling, pricking, burning or creeping on the skin (paraesthesia) • Feeling confused, restless, sweating, shaking, shivering, hallucinations (strange visions or sounds), sudden jerks of the muscles or a fast heartbeat, you may have something called Serotonin syndrome • Feeling very unwell possibly with shortness of breath (dyspnoea), difficulty in walking or walking with a shuffling gait, shaking, uncontrolled muscle twitching and a high temperature (above 38°C). This could be a rare condition known as Neuroleptic Malignant Syndrome • Rapid, slow or irregular heartbeat.

Drug Interactions

MAOI (Mono Amine Oxidase Inhibitors) medicines such as tranylcypromine, phenelzine and isocarboxazid (for depression) or selegiline (for Parkinson’s disease) , Muscle relaxants and inhaled anaesthetics , Other antidepressants such as amitriptyline or fluoxetine , Sedatives such as tranquilizers and sleeping pills , Medicines used to treat epilepsy (e.g. carbamazepine or phenytoin) , Medicines used to treat high blood pressure (e.g. clonidine) or heart disease (e.g. digoxin) , Medicines used to treat fungal infections such as ketoconazole and itraconazole , Some medicines used to treat HIV such as ritonavir and indinavir , Erythromycin (a type of antibiotic used to treat infections) , Levodopa (used for Parkinson’s disease) , St. John’s Wort (a herbal medicine) , Warfarin (a drug used to stop blood from clotting) , Phenothiazines: chlorpromazine, fluphenazine, levomepromazine, perphenazine.

Indication

It is used to treat all type of depression including depression accompanied by anxiety.

When not to Use

Do not take Trazodone HCl :• If you are allergic to trazodone hydrochloride or any of the other ingredients of this medicine . The signs of an allergic reaction include a red and lumpy skin rash, swallowing or breathing problems, swelling of your eyelids, lips, face, throat or tongue, unexplained high temperature (fever) and feeling faint • if you have recently had a heart attack • if you are a heavy drinker or if you are taking sleeping tablets • if you are under 18 years of age.

Precaution

Stopping your medicine too quickly could cause sleep problems, leave you feeling more irritable than usual and cause you to sweat more than usual.

Warning 1

If you are elderly, you may be more prone to side effects, increased caution is necessary especially when taking other medicines at the same time as Trazodone or if you have some other diseases.

Warning 2

If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer.

Warning 3

Trazodone is a drug which acts on the central nervous system and may make you feel sleepy or less alert. Do not drive, operate machinery or do anything that requires you to be alert until you know how this medicine affects you.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.