Combihale 0.5Mg/2.5Mg Nebulization Solution 2.5ml ( 1 Strip =5 ampule )

Requires Prescription (YES/NO)

Yes

Generics

 Ipratropium Bromide , Salbutamol 

Used For

Chronic Obstructive Pulmonary Disease

How it works

Ipratropium bromide is an anticholinergic (parasympatholytic) agent it appears to inhibits the vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++ which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. The bronchodilation following inhalation of ipratropium bromide is induced by local drug concentrations sufficient for anticholinergic efficacy at the bronchial smooth muscle and not by systemic concentrations.

Dosage

 Ipratropium Bromide , Salbutamol 

Side Effects

Common: Headache, dizziness, cough, throat irritation, nausea, dryness of mouth and gastrointestinal motility disorder.Uncommon: Blurred vision, mydriasis, intraocular pressure increased, eye pain, halo vision, conjunctival hyperemia, corneal oedema, glaucoma, anaphylactic reaction, hypersensitivity, angioedema of tongue, lips & face, palpitations, supraventricular tachycardia, bronchospasm, paradoxical bronchospasm, laryngospasm, pharyngeal oedema, dry throat, diarrhea, constipation, vomiting, stomatitis, rash, pruritus and urinary retention.Rare: Accommodation disorder, atrial fibrillation, heart rate increased and urticaria.

Drug Interactions

Administration of ipratropium bromide with beta-adrenergics and xanthine preparations may intensify the bronchodilator effect.Co-Administration of ipratropium bromide with other anticholinergic drugs should be avoided, as this may lead to an increase in anticholinergic adverse effects.

Indication

Ipratropium bromide is indicated as: - Bronchodilator for maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. - Adjunct to beta2-agonists in the management of acute severe asthma.

When not to Use

Ipratropium bromide is contraindicated in patients with: - Hypersensitivity to Ipratropium bromide or to any excipeint of the product. - Hypersensitivity to atropine or its derivatives.

Precaution

Ipratropium bromide is a bronchodilator for the maintenance treatment of bronchospasm associated with COPD and is not indicated for the initial treatment of acute episodes of bronchospasm where rescue therapy is required for rapid response.

Warning 1

Ipratropium bromide is an anticholinergic and its use may increase intraocular pressure. This may result in precipitation or worsening of narrow-angle glaucoma. Therefore, it should be used with caution in patients with narrow-angle glaucoma. Patients should avoid spraying ipratropium bromide inhaler into the eye.

Warning 2

Ipratropium bromide can produce paradoxical bronchospasm that can be life threatening. If this occurs, treatment with ipratropium bromide should be stopped and other treatments considered.

Warning 3

Hypersensitivity reactions including urticaria, angioedema, rash, bronchospasm, anaphylaxis and oropharyngeal edema, may occur after the a dministration of ipratropium bromide. If such a reaction occurs, therapy with ipratropium bromide should be stopped at once and alternative treatment should be considered.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.