Cofrest Syrup 120Ml

Requires Prescription (YES/NO)

Yes

Generics

Theophylline , Diphenhydramine , Ammonium Chloride , Menthol

Used For

Fever & Cough

How it works

Theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels. Ammonium chloride increases acidity by increasing the amount of hydrogen ion concentrations. Ammonium chloride can be used as an expectorant due to its irritative action on the bronchial mucosa. It acts as a counter- irritant by imparting a cooling effect and by initially stimulating nociceptors and then desensitizing them.Diphenhydramine acts as an inverse agonist at the H1 receptor, thereby reversing the effects of histamine on capillaries, reducing allergic reaction symptoms.

Dosage

Theophylline , Diphenhydramine , Ammonium Chloride , Menthol

Side Effects

Hypersensitivity , Hypokalaemia, hyperglycaemia, electrolyte imbalance , Agitation, restlessness, irritability, nervousness , Headache, insomnia, tremor, convulsions , Heart rate increased, heart rate irregular, palpitations, arrhythmia, ventricular , arrhythmia, tachycardia, sinus tachycardia, supraventricular tachycardia, atrial tachycardia and atria flutter , Hypotension, shock , Nausea, vomiting, diarrhoea, gastrointestinal disorder including gastrointestinal haemorrhage, abdominal pain, haematemesis.

Drug Interactions

Alcohol , Allopurinol , Aminoglutethimide , Barbiturates , Diazepam , Cimetidine , Disulfiram , Erythromycin , Estrogen , Fluvoxamine , Formoterol , Halothane , Imipenem , Isoniazid , Lithium , Macrolides (josamycin,spiramycin) Methotrexate (MTX) , Mexiletine , Moricizine , Pentoxifylline , Phenobarbital , Phenytoin ,Primidone , Propafenone , Propranolol , Rifampin , Sulfinpyrazone , Tacrine , Thiabendazole , Ticlopidine, Troleandomycin , Verapamil , Zileuton.

Indication

Reversible airflow obstruction, Relief of runny nose, Sneezing, Itchy, Watery eyes, Itchy nose, Itchy throat due to hay fever or allergy.

When not to Use

Hypersensitivity to the ingredients listed.

Precaution

Theophylline should be used with caution and only if absolutely necessary in the following cases: Unstable angina , Patients at risk of tachyarrhythmia , Severe hypertension , Hypertrophic obstructive cardiomyopathy , Hyperthyroidism.

Warning 1

Patients administering Ammonium chloride should be watched to the signs of ammonia toxicity.

Warning 2

Diphenhydramine may make you dizzy and can blur vision.

Warning 3

Theophylline should be used with caution in patients with hepatic or renal function impairment.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.