Co-Valid Tablets 160/12.5Mg (1 Box = 14 Tablets)

Requires Prescription (YES/NO)

Yes

Generics

Valsartan + Hydrochlorothiazide

Used For

Hypertension

How it works

Valsartan : Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. Hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of Hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss and decreases in serum potassium. The mechanism of the antihypertensive effect of thiazides is unknown.

Dosage

Valsartan + Hydrochlorothiazide

Side Effects

Uncommon : Dehydration, parasthesia, vision blurred, tinnitus, hypotension, cough, myalgia and fatigue.Very Rare : Dizziness, diarrhea and arthralgia.Not known : Syncope, non cardiogenic pulmonary oedema, impaired renal function, serum uric acid increased, serum bilirubin and serum creatinine increased, hypokalemia, hyponatremia, elevation of blood urea nitrogen and neutropenia.

Drug Interactions

Lithium , rifampin, ciclosporin or efflux transporter (eg. Ritonavir) , Hydrochlorothiazide , antidepressants, antipsychotics, antiepileptics , Allopurinol , atropine, biperiden , noradrenaline , cholestyramine or colestipol , Probenacid & Sulfinpyrazone , kaliuretic diuretics, amphotericin, carbenoxolone, penicillin G, salicylic acid derivatives or antiarrhythmics , Cyclosporine , Potassium , Tetracyclines , Alcohol, anaesthetics and sedatives , Carbamazepine , Methyldopa.

Indication

It is (Valsartan + Hydrochlorothiazide) is indicated for the treatment of hypertension to lower blood pressure.

When not to Use

The combination of Valsartan and Hydrochlorothiazide is contraindicated;• In patients with known hypersensitivity to Valsartan or Hydrochlorothiazide or to any excipient of the product.• In patients with hypersensitivity to other sulfonamide-derived drugs.• In severe hepatic impairment, biliary cirrhosis and cholestasis

Precaution

In patients with an activated renin-angiotensin system, such as volume- and/or salt-depleted patients receiving high doses of diuretics, symptomatic hypotension may occur. This condition should be corrected prior to administration of the combination of Valsartan and Hydrochlorothiazide , or the treatment should start under close medical supervision.

Warning 1

Photosensitivity reactions have been reported with thiazide diuretics. If photosensitivity reaction occurs during treatment, it is recommended to stop the treatment. If a re-administration is necessary, it is recommended to protect exposed areas to the sun or to artificial UVA.

Warning 2

Hypersensitivity reactions may occur with Hydrochlorothiazide in patients with allergy and asthma.

Warning 3

Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.