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Yes
Clomipramine Hydrochloride
Depression
Clomipramine (CMI) is presumed to influence obsessive and compulsive behaviors through its effects on serotonergic neuronal transmission. The actual neurochemical mechanism is unknown, but CMI’s capacity to inhibit the reuptake of serotonin (5-HT) is thought to be important.
Clomipramine Hydrochloride
• Drowsiness, dizziness, blurred vision or difficulty focussing your eyes, especially when treatment is started or the dose is increased. • Lightheadedness, especially when you get up too quickly from a sitting or lying position. • Dry mouth • Difficulty urinating (passing water) • Dry or sticky eyes if you wear contact lenses • Constipation • Sweating or hot flushes • Increased appetite and weight gain • Decreased appetite • Tired feeling and mental dullness • Feeling of unrest or anxiety • A compelling need to be in constant motion • Repetitive, involuntary, purposeless movements • Disturbed sleep or nightmares • Shakiness or trembling • Nausea (feeling sick), vomiting, diarrhoea • Poor appetite or weight loss • Sores in the mouth or on the tongue • Headache .
MAOI medicines , SSRIs or SNRIs (e.g. fluoxetine, paroxetine, sertraline, fluvoxamine) , warfarin , diuretic medicines, also called fluid or water tablets , some medicines for colds or allergies , anticholinergic medicines , medicines for thyroid problems , cimetidine , oestrogens , nicotine , methylphenidate , disulfiram, rifampicin , terbinafine , grapefruit/grapefruit juice or cranberry juice.
lt is used to treat: 1. Depression that is longer lasting and/or more severe than the low moods that everyone has from time to time due to the stress of everyday life ; 2. Obsessive-compulsive disorders (OCD) and phobias in adults 3. Muscle weakness in people with a sleep disorder called narcolepsy.
It is contraindicated in patients with a history of hypersensitivity to Clomipramine Hydrochloride other tricyclic antidepressants .
Since depression is a commonly associated feature of OCD, the risk of suicide must be considered. Prescriptions for Anafranil should be written for the smallest quantity of capsules consistent with good patient management, in order to reduce the risk of overdose .
All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases.
Caution is indicated in treating patients with known liver disease, and periodic monitoring of hepatic enzyme levels is recommended in such patients.
As with closely related tricyclic antidepressants, concurrent administration of Anafranil with electroconvulsive therapy may increase the risks; such treatment should be limited to those patients for whom it is essential, since there is limited clinical experience.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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