Cestonil Plus Syrup 120Ml

Requires Prescription (YES/NO)

Yes

Generics

Pizotifen , Vitamin B Complex

Used For

Migraine

How it works

Pizotifen is a tricyclic (Benzocycloheptathiophene) compound possessing structural similarities to cyproheptadine and the tricyclic antidepressant drugs. Pharmacodynamic studies demonstrate pizotifen to have powerful antiserotonin and antitryptaminic properties and marked antihistaminic effects. It also possesses weak anticholinergic effects and sedative properties.The prophylactic effect of pizotifen in migraine is associated with its ability to modify the humoral mechanisms of headache. It inhibits the permeability increasing effect of serotonin and histamine on the affected cranial vessels, thereby checking the transudation of plasmakinin so that the pain threshold of the receptors is maintained at 'normal' levels. In the sequence of events leading to the migraine attack, depletion of plasma serotonin contributes to loss of tone in the extracranial vessels. Pizotifen inhibits serotonin re-uptake by the platelets, thus maintaining plasma serotonin and preventing the loss of tone and passive distension of the extracranial arteries.

Dosage

Pizotifen

Side Effects

• Increased appetite, weight increase • drowsiness or a strong desire to sleep • fatigue (tiredness)• dizziness• nausea (feeling sick) • dry mouth • Depression • Restlessness (particularly in children) • difficutly sleeping (insomnia) • anxiety • aggression • agitation • hallucinations (seeing, feeling and hearing things that are not there) • ‘Pins and needles’ or a sensation of tingling and prickling of skin • Muscle and joint pain.

Drug Interactions

• Sleeping tablets • Sedatives (medicines for anxiety and sleeping problems) • Antihistamines, including cold and hayfever remedies.

Indication

It is used to prevent migraine-type headaches, including cluster headaches, common and classical migraine.

When not to Use

Do not take Pizotifen if you are allergic (hypersensitive) to pizotifen, or any of the other ingredients in this medicine.

Precaution

Hepatic injury has been reported, ranging from transaminase elevations to severe hepatitis. Pizotifen treatment should be discontinued if there is any clinical evidence of hepatic dysfunction during treatment and until the cause of the liver abnormality is determined.

Warning 1

Although the anticholinergic activity of pizotifen is relatively weak, caution is required in the presence of closed angle glaucoma and in patients with a predisposition to urinary retention (eg prostate hypertrophy). Dosage adjustment may be necessary in patients with kidney insufficiency.

Warning 2

Seizures as adverse effects have been observed more frequently in patients with epilepsy. Pizotifen should be used with caution in patients with a history of epilepsy.

Warning 3

Withdrawal symptoms like depression, tremor, nausea, anxiety, malaise, dizziness, sleep disorder and weight decrease have been reported following abrupt cessation of pizotifen, therefore gradual withdrawal is recommended.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.