Basagine Pen 100Units/Ml 3Ml (1 Box = 1 Pen)

Requires Prescription (YES/NO)

Yes

Generics

Insulin glargine

Used For

Diabetes Management

How it works

The primary activity of insulin glargine is the regulation of glucose metabolism. It inhibits hepatic glucose production and lowers blood glucose level by enhancing peripheral glucose uptake especially by skeletal muscle and fat. It also inhibits lipolysis in the adipocyte, inhibits proteolysis and enhances protein synthesis

Dosage

Insulin glargine

Side Effects

Very Common: Hypoglycemia is the most frequently occurring undesirable effect of insulin therapy that a patient with diabetes may suffer. Common: Lipohypertrophy, injection site reactions such as redness,pain, itching, swelling or inflammation. Uncommon: Lipoatrophy. Rare: Allergic reaction, visual impairment, retinopathy, edema (insulin may cause sodium retention and edema particularly if previously poor metabolic control is improved by intensified insulin therapy). Very Rare: Myalgia, dysgeusia.

Drug Interactions

Oral antidiabetic agents, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase (MAO) inhibitors, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics , Drugs that may reduce the blood-glucose-lowering effect include corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, estrogens and progestogens, phenothiazine derivatives, somatropin, sympathomimetic agents (e.g., epinephrine, salbutamol, terbutaline), thyroid hormones, atypical antipsychotic medicinal products (e.g., clozapine and olanzapine) and protease inhibitors , Beta-blockers, clonidine, lithium salts or alcohol , Pentamidine , sympatholytic drugs such as betablockers, clonidine, guanethidine and reserpine.

Indication

Insulin Glargine is indicated for once daily subcutaneous administration for the treatment of: *Adult and Pediatric patients with Type I Diabetes Mellitus. *Adult patients with Type II Diabetes Mellitus who require basal (long-acting) insulin for the control of hyperglycemia.

When not to Use

Insulin Glargine must not be used in patients hypersensitive to insulin glargine or any of its excipients.

Precaution

Glucose monitoring is essential for all patients receiving insulin therapy. Changes to an insulin regimen should be made cautiously and only under medical supervision.

Warning 1

In case of insufficient glucose control or a tendency to hyperglycaemic or hypoglycaemic episodes, the patient's adherence to the prescribed treatment regimen, injection sites, proper injection technique and all other relevant factors must be reviewed before the consideration of dose adjustment.

Warning 2

Insulin requirements may be altered during illness or emotional disturbance, these situations may necessitate intensified metabolic monitoring and possibly, further special measures (e.g., dose adjustment, urine tests for ketones).

Warning 3

As with all insulins, the time course of insulin glargine action may vary in different individuals or at different times in the same individual and the rate of absorption are dependent on blood supply, temperature and physical activity. All factors increasing such risk require particularly close monitoring and may necessitate dose adjustment.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store in a refrigerator (2°C–8°C). Do not Freeze .