Actrapid Hm Penfil 100Iu 3Ml

Requires Prescription (YES/NO)

Yes

Generics

Human Insulin

Used For

Diabetes Management

How it works

The major effects of insulin on carbohydrate homoeostasis following its binding to specific cell-surface receptors on insulin-sensitive tissues, notably the liver, muscles and adipose tissue. It inhibits hepatic glucose production and enhances peripheral glucose disposal thereby reducing blood-glucose concentration. It also inhibits lipolysis thereby preventing the formation of ketone bodies.

Dosage

Human Insulin

Side Effects

Hypoglycemia : They may include cold sweat, cool pale skin, nervousness or tremor, anxious feeling, unusual tiredness or weakness, confusion, difficulty in concentration, headache, nausea and palpitation. Severe hypoglycemia may lead to unconsciousness and may result in temporary or permanent impairment of brain function or even death , Weight gain , Oedema and refraction anomalies , . Local hypersensitivity reactions (redness, swelling and itching at the injection site) , Lipodystrophy , generalised skin rash, itching, sweating, gastrointestinal upset, angioneurotic oedema, difficulties in breathing, palpitation and reduction in blood pressure.

Drug Interactions

Beta blocking agent Oral hypoglycemic agents (OHA), octreotide, monoamine oxidase inhibitor (MAOI), non selective beta blocking agents, angiotensin converting enzyme (ACE) inhibitors, salicylates, alcohol and alcohol steroids , Oral contraceptives, thiazides, glucocorticoids, thyroid hormones and sympathomimetics, danazol etc.

Indication

It is indicated for the treatment of : Patients with Type I diabetes mellitus. - Patients with Type II diabetes mellitus either alone or in combination with oral anti-diabetic agents. - Patients with gestational diabetes. - The emergency management of diabetic ketoacidosis.

When not to Use

Insulin is contraindicated in: - Patients with hypersensitivity to any components of this medication. - Patients with hypoglycemia. - Patients in coma due to hyperglycemia.

Precaution

Care is also necessary during excessive exercise. Hypoglycemia caused by metabolic effects and increased insulin absorption is the usual response, but hyperglycemia may sometimes occur. Adjustment of insulin dosage may also be necessary if patients change their level of physical activity or change their usual diet.

Warning 1

Insulin requirements may be increased during illness or emotional disturbances.

Warning 2

The use of insulin necessitates monitoring of therapy, such as the testing of blood or urine for glucose concentrations and the urine for ketones, by the patient .

Warning 3

Local reactions, characterised hypersensitivity may produce urticaria, angioedema and very rarely anaphylactic reactions. If continued therapy with insulin is essential, hyposensitisation procedures may need to be performed.

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store in a refrigerator (2°C–8°C). Do not Freeze .