Actfree Tablets (1 Strip = 10 Tablets)

Requires Prescription (YES/NO)

No

Generics

Glucosamine Sulphate ,Chondroitin Sulphate Sodium

Used For

Osteoarthritis

How it works

Glucosamine : Glucosamine is a normal constituent of polysaccharide chains of cartilage matrix and synovial fluid glucosaminoglycans. It stimulates the synthesis of physiological glycosaminoglycans and proteoglycans by chondrocytes and hyaluronic acid by synoviocytes. Glucosamine Sulfate also inhibits the activity of cartilagedestroying enzymes such as collagenase and phospholipase A2, as well as the generation of other tissue damaging substances such as superoxide radicals or the activity of lysosomal enzymes that contributes to its mild anti-inflammatory effects. Chondroitin Sulfate Sodium : Chondroitin Sulfate increases the synthesis of cartilage matrix components such as hyaluronic acid and proteoglycans and reduces the degradation of cartilage matrix components, specifical ly col lagen II, glycosaminoglycans and proteoglycans, and reduces necrosis and apoptosis of chondrocytes. Chondroitin Sulfate also reduces the activity of collagenase, Nacetylglucosaminidase, aggrecanase 1 and 2, matrix metalloproteinase (MMP) 3, MMP-9, MMP-13, MMP-14, cathepsin B and elastase and elicits an anti-inflammatory effect through diverse mechanisms.

Dosage

Glucosamine Sulphate ,Chondroitin Sulphate Sodium

Side Effects

Glucosamine: Nausea, diarrhea, epigastric pain/ tenderness, constipation, dyspepsia, indigestion, heartburn, headache, abdominal pain, palpitation, drowsiness, somnolence and skin reactions. Chondroitin Sulfate Sodium: Nausea, diarrhea, mild stomach pain, constipation, swollen eyelids, hair loss, leg swelling, heart burn and irregular heartbeat.

Drug Interactions

Coumarins anticoagulants, blood pressure medicines , NSAIDs, hypoglycemic agents.

Indication

It is used as a dietary supplement: - To relieve pain and improve function in patients with mild to moderate osteoarthritis - In joint pain - In cartilage degeneration - In tendonitis - In bursitis .

When not to Use

It is contraindicated in: - Patients with hypersensitivity to any of the ingredients of the product. - Patients with shellfish allergy. - Patients with prostate cancer or are those that are at high risk of developing it . - Children and adolescents under the age of 18 years .

Precaution

In patients with impaired glucose tolerance , monitoring of the blood glucose levels and where relevant , insulin requirements is recommended before start of treatment periodically during treatment.

Warning 1

Asthma symptoms may exacerbate after initiation of Glucosamine and Chondroitin Sulfate therapy . Caution should be exercised during treatment in patients with pre-existing asthma.

Warning 2

Administration of this product to patients with severe hepatic or renal insufficiency should be under appropriate medical supervision.

Warning 3

The use of Glucosamine and Chondroitin Sulfate is not recommended during breast feeding .

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.