{"product_id":"ranola-500mg-tablets-20s","title":"Ranola Tablets 500Mg (1 Strip = 10 Tablets)","description":"\u003cdiv class=\"productDescription_descriptionSectionGroup__cgws9 MuiBox-root css-0\"\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper__qrHVG\"\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper2___OSGQ\" id=\"SPECIFICATION\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__Jflgt css-9l3uo3\"\u003e\u003cb\u003eRanola 500mg Tablet 1 Box = 2 Strips\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__Jflgt css-9l3uo3\"\u003e\u003cb\u003eSpecification\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eRequires Prescription (YES\/NO)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eYes\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eGenerics\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eRanolazine\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eUsed For\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAngina\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eHow it works\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe mechanism of action of ranolazine is largely unknown. Ranolazine may have some antianginal effects by inhibition of the late sodium current in cardiac cells. This reduces intracellular sodium accumulation and consequently decreases intracellular calcium overload. Ranolazine, via its action to decrease the late sodium current, is considered to reduce these intracellular ionic imbalances during ischaemia. This reduction in cellular calcium overload is expected to improve myocardial relaxation and thereby decrease left ventricular diastolic stiffness. Clinical evidence of inhibition of the late sodium current by ranolazine is provided by a significant shortening of the QTc interval and an improvement in diastolic relaxation in an open-label study of 5 patients with a long QT syndrome (LQT3 having the SCN5A ?KPQ gene mutation).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper2___OSGQ\" id=\"USAGE AND SAFETY\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__Jflgt css-9l3uo3\"\u003e\u003cb\u003eUsage And Safety\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eDosage\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eRanolazine\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eSide Effects\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAnorexia, decreased appetite, dehydration , hyponatremia , anxiety, insomnia, confusional state, hallucination , disorientation , dizziness, headache , lethargy, syncope, hypoaesthesia, somnolence, tremor, postural dizziness, paresthesia , amnesia, depressed level of consciousness, loss of consciousness, coordination abnormal, gait disturbance, parosmia , myoclonus. Eye disorders , blurred vision, visual disturbance, diplopia , Ear and labyrinth disorders , vertigo, tinnitus , impaired hearing , hot flush, hypotension , peripheral coldness, orthostatic hypotension .\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eDrug Interactions\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eClarithromycin, telithromycin , itraconazole, ketoconazole, voriconazole, posaconazole, protease inhibitors, nefazodone, quinidine, dofetilide, or sotalol , erythromycin , fluconazole , ciclosporin, diltiazem or verapamil , phenytoin, carbamazepine, or phenobarbital, terfenadine, astemizole, mizolastine, disopyramide, procainamide, imipramine, doxepin, amitriptyline, bupropion, psychosis, efavirenz , cyclophosphamide , simvastatin, lovastatin, atorvastatin , tacrolimus, ciclosporin, sirolimus, everolimus .\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eIndication\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIt is indicated for the treatment of chronic angina.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eWhen not to Use\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDo not take - if you are allergic to ranolazine or any of the other ingredients of this medicine ; if you have severe kidney problems ; if you have moderate or severe liver problems ; if you are using certain medicines to treat bacterial infections (clarithromycin, telithromycin), fungal infections (itraconazole, ketoconazole, voriconazol, posaconazol), HIV infection (protease inhibitors), depression (nefazodone) or heart rhythm disorders (e.g. quinidine, dofetilide, or sotalol).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper2___OSGQ\" id=\"PRECAUTIONS\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__Jflgt css-9l3uo3\"\u003e\u003cb\u003ePrecautions\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003ePrecaution\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCaution should be taken in case of: • Concomitant administration of moderate CYP3A4 inhibitors . • Concomitant administration of P-gp inhibitors . • Mild hepatic impairment . • Mild to moderate renal impairment (creatinine clearance 30–80 ml\/min). • Elderly • Patients with low weight (= 60 kg) • Patients with moderate to severe CHF (NYHA Class III–IV) .\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper2___OSGQ\" id=\"WARNINGS\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__Jflgt css-9l3uo3\"\u003e\u003cb\u003eWarnings\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eWarning 1\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eIn patients with a combination of these factors, additional exposure increases are expected. Dose dependent side effects are likely to occur. If Ranolazine is used in patients with a combination of several of these factors, monitoring of adverse events should be frequent, the dose reduced, and treatment discontinued, if needed.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eWarning 2\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCo-administration with CYP3A4 inducers is expected to lead to lack of efficacy. Ranolazine should not be used in patients treated with CYP3A4 inducers (e.g. rifampicin, phenytoin, phenobarbital, carbamazepine, St. John’s Wort).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eWarning 3\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCaution should be observed when treating patients with a history of congenital or a family history of long QT syndrome, in patients with known acquired QT interval prolongation, and in patients treated with drugs affecting the QTc interval .\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper2___OSGQ\" id=\"ADDITIONAL INFORMATION\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__Jflgt css-9l3uo3\"\u003e\u003cb\u003eAdditional Information\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003ePregnancy category\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAlways consult your physician before using any medicine.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3__g15Bl\"\u003e\n\u003cp class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__IJgZU css-9l3uo3\"\u003e\u003cb\u003eStorage (YES\/NO)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eStore this medicine at room temperature, away from direct light and heat.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"HIGHNOON LABORATORIES LTD.","offers":[{"title":"Default Title","offer_id":43909294948538,"sku":"ranola-500mg-tablets-14s","price":310.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0658\/7511\/6218\/files\/Ranola500mgTablet.jpg?v=1722966719","url":"https:\/\/multanpluspharmacy.com\/products\/ranola-500mg-tablets-20s","provider":"Multan Plus Pharmacy","version":"1.0","type":"link"}